Nucleosides and Analogues
Apexbio Technology LLC Primaquine Diphosphate 63-45-6 10mM (in 1mL DMSO)
Primaquine Diphosphate is an 8-aminoquinoline derivative utilized primarily as an antimalarial agent targeting the extraerythrocytic liver stage of malaria parasites While its precise IC50 values remain unspecified primaquine s biological activity involves interference with nucleic acid function subsequently disrupting protein synthesis pathways and lipid biosynthesis and inducing membrane disturbances In vitro primaquine has been applied in cell culture models to investigate antiviral effects demonstrating dose-dependent inhibition of Newcastle disease virus replication and modulation of viral RNA synthesis In vivo experiments using radiolabeled primaquine-loaded liposomes in murine models illustrate pronounced hepatic accumulation Clinically this compound is employed as prophylaxis against malaria infections (e g Plasmodium falciparum and P vivax)
Medchemexpress LLC Flavin adenine dinucleotide | 146-14-5 | 98.9% | 100 MG
Flavin adenine dinucleotide (FAD) is a redox cofactor, a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism. It is intended for research use only.
- Redox cofactor involved in enzymatic reactions in metabolism.
- Available in various quantities as solid or solution.
Medchemexpress LLC ATP-polyamine-biotin | 1800401-93-7 | 98.1% | 25 MG
ATP-polyamine-biotin is the first cell-permeable ATP analogue and serves as an efficient kinase cosubstrate. It promotes biotin labeling of kinase substrates in live cells.
- First cell-permeable ATP analogue
- Efficient kinase cosubstrate
- Promotes biotin labeling of kinase substrates in live cells
Medchemexpress LLC Adenosine 5'-triphosphate | 56-65-5 | 95.7% | 25 MG
ATP (Standard) (Adenosine 5'-triphosphate (Standard)) is the analytical standard of ATP, intended for research and analytical applications. It is a central component of energy storage and metabolism in vivo, provides metabolic energy to drive metabolic pumps, and serves as a coenzyme in cells. It is also an important endogenous signaling molecule in immunity and inflammation. It is commonly used in qualitative, quantitative, and methodological research experiments.
- Used as an analytical standard for research and analytical applications, including HPLC, GC, and MS.
- Synergistically activates the NLRP3 inflammasome in HGFs.
- Induces secretion of IL-1β, KC, and MIP-2 from BMDMs in a caspase-1 activation-dependent manner.
- Promotes neutrophil chemotaxis in vitro.
- Protects mice against bacterial infection.
- Induces the secretion of IL-1β, KC, and MIP-2 and neutrophils recruitment in vivo.
Medchemexpress LLC L-Guanosine | 26578-09-6 | 98.0% | 283.24 | 25 MG
L-Guanosine is the L-configuration of Guanosine. It is a purine nucleoside that exhibits anti-herpesvirus activity and can be used to prepare supramolecular hydrogel. This product ships at room temperature and should be stored solid at 4°C, protected from light. Solutions can be stored at -80°C for 6 months or -20°C for 1 month, also protected from light.
- Purine nucleoside
- Exhibits anti-herpesvirus activity
- Can be used to prepare supramolecular hydrogel
- Ships at room temperature
- Solid storage: 4°C, protect from light
- In solvent storage: -80°C for 6 months or -20°C for 1 month, protect from light
Medchemexpress LLC 6H-Purin-6-one, 2-amino-1,9-dihydro-9-β-L-ribofuranosyl- | 26578-09-6 | 98.0% | 283.24 | 250 MG
L-Guanosine is the L-configuration of Guanosine. This purine nucleoside exhibits anti-herpesvirus activity and can be used in the preparation of supramolecular hydrogel.
- L-configuration of guanosine
- Purine nucleoside
- Exhibits anti-herpesvirus activity
- Can be used in the preparation of supramolecular hydrogel
- Functions as a nucleoside antimetabolite/analog
- Acts as an inhibitor
Medchemexpress LLC Nicotinamide | 98-92-0 | 99.9% | 1 G
Nicotinamide, also known as Niacinamide, is a form of vitamin B3. It functions as an inhibitor of SIRT1 and SIRT2, increasing cellular NAD+, ATP, and ROS levels. It is involved in various biological processes, including tumor growth inhibition and anti-HBV activity.
- SIRT2 inhibitor (IC50: 2 μM)
- SIRT1 inhibitor (IC50: 50-180 μM)
- Increases cellular NAD+, ATP, and ROS levels
- Inhibits tumor growth
- Possesses anti-HBV activity
- Promotes pancreatic cell differentiation
- Reduces cell number in melanoma cells
Medchemexpress LLC 7-Methyl-guanosine-5'-triphosphate sodium (m7GTP sodium) | 50 MG
7-Methyl-guanosine-5'-triphosphate (m7GTP) sodium is a guanosine 5'-phosphate.
- Potent cap-dependent translation inhibitor.
Apexbio Technology LLC Chloroquine diphosphate 50-63-5 10mM (in 1mL H2O)
Chloroquine diphosphate is an antimalarial agent and inhibitor of TLR7 and TLR9 commonly used in biomedical research to modulate autophagic processes On the cellular level chloroquine diphosphate promotes autophagy through cell cycle arrest at the G1 phase involving increased expression of p27 and p53 and decreased levels of CDK2 and cyclin D1 Additionally chloroquine diphosphate enhances sensitivity of cancer cells toward chemotherapy and radiotherapy treatments by elevating autophagy and apoptotic responses In vitro studies demonstrated dose-dependent activity with reported IC50 values typically ranging from approximately 15 to 40 M depending on cell types This compound is widely utilized as an autophagy modulator and therapeutic adjuvant in tumor cell models
Medchemexpress LLC TFEB Decoy ODN sodium | 90.2% | 1 MG
TFEB Decoy ODN sodium is a synthetic oligonucleotide featuring a hairpin ring structure, engineered to inhibit Transcription factor EB (TFEB). It has demonstrated efficacy in inhibiting fibrosis and autophagy within a UUO mouse model, and also exhibits anti-inflammatory effects.
- Synthetic oligonucleotide with a hairpin ring structure.
- Designed to inhibit transcription factor EB (TFEB).
- Inhibited fibrosis in a UUO mouse model.
- Inhibited autophagy in a UUO mouse model.
- Showed anti-inflammatory effects.
Apexbio Technology LLC ATP disodium salt 987-65-5 10mM (in 1mL H2O)
ATP disodium salt (CAS 987-65-5) is a nucleotide derivative serving as the primary energy carrier in cellular metabolism It provides chemical energy through phosphate group transfer reactions facilitating numerous biochemical processes In addition to its metabolic functions ATP acts as a coenzyme involved in intracellular signaling and protein phosphorylation pathways Due to these biochemical roles ATP disodium salt is widely utilized in research exploring cellular metabolism signaling mechanisms and energy regulation pathways Recently ATP s function as a signaling molecule in immune responses and inflammation modulation has also gained attention
Medchemexpress LLC Adenosine | 58-61-7 | 100.0% | 25 G
Adenosine is a ubiquitous and BBB-permeable endogenous autacoid. It acts through four G protein-coupled receptors: A1, A2A, A2B, and A3. This compound impacts nearly all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation. It is for research use only and not sold to patients.
- Acts through four G protein-coupled receptors: A1, A2A, A2B, and A3
- Impacts neuronal activity, vascular function, platelet aggregation, and blood cell regulation
- Ubiquitous and BBB-permeable endogenous autacoid
- Displays cytoprotective function
- Purity: 99.96%
- Molecular weight: 267.25
- Appearance: Solid, white to off-white
Medchemexpress LLC Adenosine 2',5'-diphosphate sodium | 154146-84-6 | MFCD00009228 | 1 MG
Adenosine 2',5'-diphosphate sodium is a potent competitive antagonist of the P2Y1 receptor, and also exhibits non-selective antagonism at recombinant and human platelet P2X1 receptors. This endogenous metabolite is supplied as a white to off-white solid with 99.0% purity.
Key Features & Applications:
- Competitive P2Y1 antagonist
- Non-selective P2X1 receptor antagonism in platelets
- Research use only
Apexbio Technology LLC 2-Amino-ATP(Synonyms: 2-NH2-ATP, 2-Aminoadenosine triphosphate, 2-Amino-adenosine-5'-triphosphate, 2-Amino-ATP (free acid)), 100ul (100 mM).
2-Amino-ATP is a modified nucleotide structurally related to ATP (adenosine triphosphate) featuring an amino substitution at the adenine ring s 2-position It acts as an ATP analog capable of competitively binding at the active sites of ATP-dependent enzymes potentially modulating their enzymatic activity and influencing downstream signaling pathways In research settings 2-Amino-ATP serves as a molecular tool to examine substrate specificity mechanistic aspects of ATP-binding enzymes (e g kinases and ATPases) and nucleotide-dependent receptor interactions facilitating studies of nucleotide signaling and cellular metabolism